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KMID : 0357220040160020063
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Journal of Korean Society Physical Therapy
2004 Volume.16 No. 2 p.63 ~ p.71
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The effects of Electrical Stimulation Therapy on NT-3 Expression in the Denervated Neuromuscular Junction in Rat
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남기원
구현모/천송희/이윤섭/강종호/김진상
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Abstract
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Denervated skeletal muscle produces muscle atrophy as well as changes at the neuromuscular junction which leads to terminal axonal sprouting and an ultrastructural remodeling. NT-3 is expressed in adult muscle and motoneurons. Normally NT-3 has a potential role in regulating adult neuromuscular jungtion and recovering following muscle atrophy. Also, it could influence synaptic neurotransmission between motoneurons and skeletal muscle cells. The purpose of this study was to investigate the effect of electrical stimulation therapy(EST) on NT-3 expression in neuromuscular junction following sciatic nerve transsection in rats. After EST application during 7 days, the immunoreactivity of NT-3 was increased in neuromuscular junction
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KEYWORD
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